Lars Karlsson Selected Research

1- (3- (4- (6- Chloro- 2,3- dihydro- 3- methyl- 2- oxo- 1H- benzimidazol- 1- yl)- 1- piperidinyl)propyl)- 4,5,6,7- tetrahydro- 5- (methylsulfonyl)- 3- (4- (trifluoromethyl)phenyl)- 1H- pyrazolo(4,3- c)pyridine

1/2004

Identification of a potent and selective noncovalent cathepsin S inhibitor.

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Lars Karlsson Research Topics

Disease

6	Inflammation (Inflammations) 05/2014 - 04/2004
5	Asthma (Bronchial Asthma) 12/2013 - 11/2004
4	Hypersensitivity (Allergy) 12/2007 - 01/2004
3	Abdominal Aortic Aneurysm 01/2020 - 03/2003
2	Ischemia 01/2020 - 12/2009
2	Rheumatoid Arthritis 01/2018 - 12/2007
2	Pneumonia (Pneumonitis) 05/2010 - 07/2009
2	Peritonitis 06/2007 - 04/2004
1	Peripheral Arterial Disease 12/2020
1	Chronic Limb-Threatening Ischemia 12/2020
1	Intermittent Claudication 12/2020
1	Neuralgia (Stump Neuralgia) 08/2020
1	Peripheral Nerve Injuries 08/2020
1	Hyperalgesia 08/2020
1	Cerebral Hemorrhage 01/2020
1	Thrombosis (Thrombus) 01/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Stroke (Strokes) 01/2018
1	Periprosthetic Fractures 12/2016
1	Hip Fractures (Intertrochanteric Fractures) 12/2016
1	Necrosis 07/2015
1	Synovitis 05/2014
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2013
1	Epstein-Barr Virus Infections 07/2011
1	Hypoxia (Hypoxemia) 12/2009
1	Reperfusion Injury 12/2009
1	Infections 07/2009
1	Melanoma (Melanoma, Malignant) 03/2008
1	Malaria 12/2007
1	Actinic Keratosis 12/2007
1	Lung Neoplasms (Lung Cancer) 12/2007
1	Basal Cell Carcinoma (Rodent Ulcer) 12/2007
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/2007
1	Condylomata Acuminata (Genital Wart) 12/2007
1	Otitis 06/2007
1	Edema (Dropsy) 06/2007
1	Pruritus (Itching) 01/2007
1	Hematologic Neoplasms (Hematological Malignancy) 04/2006

Drug/Important Bio-Agent (IBA)

3	Interleukin-6 (Interleukin 6)IBA 01/2018 - 04/2006
2	cathepsin SIBA 08/2020 - 05/2005
2	CytokinesIBA 08/2020 - 04/2006
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 03/2008
2	Interleukin-8 (Interleukin 8)IBA 05/2014 - 03/2008
2	Leukotriene B4IBA 05/2010 - 09/2006
2	ZymosanIBA 06/2007 - 04/2004
2	Histamine (Histamine Dihydrochloride)FDA Link 01/2007 - 11/2004
2	Histamine H4 ReceptorsIBA 01/2007 - 06/2006
2	Histamine Receptors (Histamine Receptor)IBA 01/2007 - 11/2004
2	Histamine Antagonists (Antihistamines)IBA 01/2007 - 11/2004
1	Pharmaceutical PreparationsIBA 12/2020
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2020
1	Analgesics (Analgesic Drugs)IBA 08/2020
1	TicagrelorIBA 01/2020
1	Hemoglobins (Hemoglobin)IBA 01/2020
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2020
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2020
1	Growth Hormone (Somatotropin)IBA 01/2020
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2018
1	Biological ProductsIBA 01/2018
1	CreatinineIBA 01/2018
1	LigandsIBA 07/2015
1	AntibodiesIBA 07/2015
1	CD226 antigenIBA 07/2015
1	benzofuranIBA 02/2013
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 07/2011
1	HydrolasesIBA 05/2010
1	Leukotriene A4IBA 05/2010
1	tacrolimus binding protein 1BIBA 12/2009
1	UbiquitinIBA 12/2009
1	MyoglobinIBA 12/2009
1	Tacrolimus Binding Protein 1A (FKBP12)IBA 12/2009
1	Proteins (Proteins, Gene)FDA Link 12/2009
1	ImmunophilinsIBA 12/2009
1	Messenger RNA (mRNA)IBA 12/2009
1	Azithromycin (Zithromax)FDA LinkGeneric 07/2009
1	Mitogen-Activated Protein Kinase 3IBA 03/2008
1	AgarIBA 03/2008
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 12/2007
1	OligodeoxyribonucleotidesIBA 12/2007
1	Chloroquine (Aralen)FDA LinkGeneric 12/2007
1	Quinacrine (Mepacrine)IBA 12/2007
1	Imiquimod (Aldara)FDA LinkGeneric 12/2007
1	piperidineIBA 06/2007
1	Carboxylic AcidsIBA 06/2007
1	1- (4- (benzothiazol- 2- yloxy)benzyl)piperidine- 4- carboxylic acidIBA 06/2007
1	cysteinyl-leukotrieneIBA 06/2007
1	Arachidonic Acid (Vitamin F)IBA 06/2007
1	zileuton (Zyflo)FDA Link 06/2007
1	LipoxinsIBA 06/2007
1	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 04/2006
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2006
1	ChemokinesIBA 04/2006
1	Monocyte Chemoattractant ProteinsIBA 04/2006
1	InterferonsIBA 04/2006

Therapy/Procedure

2	Therapeutics 12/2013 - 12/2007
1	Stents 12/2020
1	Cranial Irradiation 01/2018
1	Arthroplasty 12/2016
1	Hip Replacement Arthroplasty (Total Hip Replacement) 12/2016